Fatal pertussis infection – an emerging disease?
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Pertussis infection in fully vaccinated children in day-care centers, Israel.
We tested 46 fully vaccinated children in two day-care centers in Israel who were exposed to a fatal case of pertussis infection. Only two of five children who tested positive for Bordetella pertussis met the World Health Organization's case definition for pertussis. Vaccinated children may be asymptomatic reservoirs for infection.
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Objective(s): After decades of containment, pertussis disease, caused by Bordetella pertussis seems to be re-emerging and still remains a major cause of reported vaccine-preventable deaths worldwide. The current licensed whole-cell vaccines display reactogenicity while acellular vaccines are expensive and do not induce Th1-type immune responses that are required for optimum protection against t...
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In this study children were more commonly exposed to pertussis by a sibling (22/26) than a parent, and 25 ofthe 26 children and adults responsible for transmitting the infection had typical disease. Atypical disease occurred in older children and parents but was almost exclusively associated with secondary rather than primary infection. Furthermore, isolation of B pertussis (which may reflect a...
متن کاملSeroprevalence of IgG Antibodies against Bordetella pertussis in Different Age Groups in Tehran, Iran
Background and Aims: Pertussis is a highly contagious, vaccine-preventable disease. Determination of the seroepidemiology of pertussis makes possible the evaluation of pertussis immunity in a population. In this study, we determined the seroprevalence of Bordetella pertussis IgG antibodies in different age groups in Tehran, Iran. Materials and Methods: Overa...
متن کاملExtraction of Outer membrane Vesicles from Vaccinal Strain of Bordetella Pertussis as the First Step of a Vaccine Candidate Study Against Pertussis Infection
Background: Pertussis is still one of the major public health problems. The increase of the disease emerged in recent decades due to the replacement of the reactogenic whole cell vaccine with the safer acellular vaccine and the genetic diversity of the bacterium. As outer membrane vesicles (OMVs) obtained from Bordetella pertussis contains surface immunogenic antigen in its structure, it has an...
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تاریخ انتشار 2013